Relationship between Malaria and Sickle Cell Desease among Out-Patients Attending Genotype Test

Abstract

One hundred and eleven (111) out-patients attending Murtala Mohammad Specialist Hospital in Kano State Nigeria, with a mean age of 13.40 years and male to female ratio 25:12 were examined for malaria and sickle cell diseases. The blood sample of each patient from the tip of the thump finger pierced with lancet was collected in test tube containing sodium chloride and water in solution for haemoglobin genotype test and on slide for malarial parasite test, the samples collection was on weekly bases for a period of four weeks. The number of patients who were malaria infected was 70 with male-female ratio of 24:11 and non-malaria infected patients were 41. While number of normal haemoglobin (HbAHbA) patients was 63, sickle cell allele carrier were 32 (HbAHbs) and 16 sicklers (HbsHbs) with male-female ratio of 5:3. The sampled patients have 29% allelic frequency of sickle cell allele. The relationship between malaria and sickle cell disease that maintained sickle cell allele in malaria community did not differ significantly among the patients (P?0.05).

DOI: 10.5901/ajis.2013.v2n6p41